. 2022 Jan 27;10(2):304. doi: 10.3390/microorganisms10020304

Table 2.

Studies included in the review reporting the presence of sleep-wake and circadian disorders after TBEV in children and adults.

Study	Study Population	Number of Subjects	Assessed Sequelae	Prevalence Acute Phase (<1 month)	Prevalence (1–6 months)	Prevalence (6–12 months)	Prevalence Chronic (>12 months)
Krbková, 2015 [41]	Children	170	Sleepiness	5.9% (n = 10)	n.a.	n.a.	n.a.
			Sleep-wake inversion	0.59% (n = 1)	n.a.	n.a.	n.a.
			Fatigue ¹	n.a.	52% (n = 88)	0%	n.a.
Schmolck, 2005 [42]	Children	19	Fatigue	42.1% (n = 8)	n.a.	n.a.	n.a.
Schmolck, 2005 [42]	Children	19	Somnolence	21.05% (n = 4)	n.a.	n.a.	n.a.
Lešničar, 2003 [43]	Children	371	Fatigue	90.8% (n = 337)	n.a.	n.a.	n.a.
Lešničar, 2003 [43]	Children	371	Somnolence	7.2% (n = 27)	n.a.	n.a.	n.a.
Fowler, 2013 [44]	Children	55	Fatigue	n.a.	n.a.	n.a.	34.5% (n = 19)
Fowler, 2013 [44]	Children	55	Restlessness	n.a.	n.a.	n.a.	20% (n = 11)
Engman, 2012 [45]	Children	8	Fatigue	n.a.	n.a.	n.a.	37.5% (n = 3)
Rezza, 2015 [46]	Adults	60 ²	Tiredness	38.3% (n = 23)	n.a.	n.a.	n.a.
Rezza, 2015 [46]	Adults	60 ²	Insomnia	3.3% (n = 2)	n.a.	n.a.	n.a.
Czupryna, 2010 [23]	Adults	687	Sleep disorders	12.4% (n = 77)	n.a.	n.a.	13.2% (n = 5)
Mickiene, 2002 [19]	Adults	94	Fatigue	62.8% (n = 59)	n.a.	n.a.	Not specified ³
Czupryna, 2018 [47]	Adults	221 ⁴	Sleep disorders	10% (n = 22)	4.5% (n = 10)	n.a	n.a.
Czupryna, 2018 [47]	Adults	221 ⁴	Fatigue	0% (n = 0)	21.3% (n = 47)	n.a.	n.a.
Karelis, 2011 [48]	Adults	228	Somnolence	15.4% (n = 35)	n.a.	n.a.	n.a.
			Fatigue	44% (n = 44)	n.a.	n.a.	61% (n = 61)
			Sleep disturbances	n.a.	n.a.	n.a.	42% (n = 42)
Lotric- Furlan, 2017 [49]	Vaccinated adults	39	Sleep disturbances	41% (n = 16)	5.1% (n = 2)	n.a.	n.a.
Lotric- Furlan, 2017 [49]	Adults	78	Sleep disturbances	25.6% (n = 20)	7.7% (n = 6)	n.a.	n.a.
Hansson, 2020 [50]	Vaccinated adults	53	Fatigue	98% (n = 52)	79% (n = 33) (1–3 mo.) 87% (n = 13) (3–6 mo.)	44% (n = 8)	n.a.
Bogovic, 2018 [51]	Adults	420	Fatigue	n.a.	21.4% (n = 65)	15.9% (n = 33)	6.4% (n = 27)
Bogovic, 2018 [51]	Adults	420	Sleep disorders	n.a.	2.6% (n = 8)	2.9% (n = 6)	2.9% (n = 12)
Veje, 2016 [52]	Adults	96	Fatigue	74% (n = 71)	65% (n = 52) (0.5–2 mo.) 58% (n = 21) (3–6 mo.)	n.a.	n.a.
Veje, 2021 [53]	Adults	22	Fatigue	n.a	n.a.	n.a	31.8% (n = 7)
Veje, 2021 [53]	Adults	22	Excessive Daytime Sleepiness	n.a.	n.a.	n.a.	54.5% (n = 12)

¹ Exact percentage of fatigue was not provided but provided in a category with headache. ² 367 cases were analyzed but only for 60 cases were sequelae reported. ³ Exact percentage of fatigue was not provided, but only listed as a common complaint. ⁴ 1072 cases were assessed, but only 221 developed sequelae.