Figure 2.

Oral Food Challenges: Food challenge outcome in active (singles, doubles, and mixtures) and control groups 2–4 years after start of study. Oral food challenges (up to 8 g of total protein from the 10-food allergen mixture) were conducted between 2–4 years after the start of the study in a facility with trained personnel with staged, monitored standard methods. Each food challenge consisted of several escalating doses of the food protein in flour or powder form concealed in an appropriate vehicle, such as applesauce or pudding, ingested by the participant every 15 min as tolerated. Typically challenges started with 2 mg and escalated upto a max of 8 g of total food protein as per our validated methods [26,27,28].