Table 2.
The particle size, structure, and lipid components of the commercial liposomal products.
| Product Name | Size | Structure | Main Composition |
|---|---|---|---|
| Doxil/Caelyx | ca. 100 nm | SUVs | HSPC, MPEG-DSPE, Chol |
| AmBisome | 50–100 nm [41] | SUVs | HSPC, DSPG, Chol |
| DaunoXome | 45–80 nm [42] | SUVs | DSPC, Chol |
| Marqibo | 130–150 nm | SUVs | SM, Chol |
| Onivyde | ca. 110 nm | SUVs | DSPC, MPEG2000-DSPE, Chol |
| Visudyne | <100 nm | SUVs [43] | EPC, DMPC |
| Shingrix | 50–100 nm [44] | SUVs | DOPC, Chol |
| Arikaye | 200–300 nm [45] | LUVs | DPPC, Chol |
| Vyxeos | ca. 110 nm | bilammer | DSPC, DSPG, Chol |
| Myocet | 80–90 nm [42] | MLVs [46] | EPC, Chol |
| Mepact | 2.0–3.5 μm [47] | MLVs | POPC, OOPS |
| DepoCyt | 20 μm [42] | MVLs | DOPC, DPPG, Chol, triolein |
| Exparel | 24–31 μm [42] | MVLs | DEPC, DPPG, Chol, tricaprylin |
| DepoDur | 17 to 23 μm | MVLs | DOPC, DPPG, Chol, triolein, tricaprylin |
Abbreviations: fully hydrogenated soy phosphatidylcholine (HSPC), egg phosphatidylcholine (EPC), distearoylphosphatidylcholine (DSPC), dioleoyl phosphatidylcholine (DOPC), dierucoyl phosphatidylcholine (DEPC), palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), dipalmitoyl phosphatidylcholine (DPPC), dimyristoylphosphatidylcholine (DMPC), dipalmitoylphosphatidylglycerol (DPPG), distearoylphosphatidylglycerol (DSPG), dioleoyl phosphatidylserine(DOPS), dioleoylphosphatidylserine (OOPS), cholesterol (Chol), sphingomyelin (SM), N-(carbonyl-methoxypolyethlyeneglycol-2000)-distearolyphosphatidylethanolamine (MPEG-2000-DSPE).