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. 2022 Jan 21;12(2):157. doi: 10.3390/life12020157

Figure 4.

Figure 4

αB7-H3/CD3 mediates T cell cytotoxicity against B7-H3 expressing tumor cells in vitro. (a) Cytotoxic activity of PBMCs in U-87 MG cells mediated by αB7-H3/CD3 or other antibodies was measured by flow cytometry. n = 3, p-value for mAb mix vs. bsAb: *** p < 0.001; (b–h) αB7-H3/CD3 demonstrated cytotoxic activity against multiple tumor cell lines (U-87 MG, A498, SKOV3, MDA-MB-231, HepG2, K562, and Raji) with various levels of B7-H3 expression, E:T = 10:1. n = 3, mAb mix, anti-CD3 and anti-B7-H3 mAb mixture; bsAb, αB7-H3/CD3.