Figure 6.

αB7-H3/CD3 inhibits tumor growth in xenograft models using human PBMC-engrafted NCG mouse models. (a,c) Schematic map of the development of U-87 MG (a) and SKOV3 (c) xenograft model. U-87 MG or SKOV3 were subcutaneously implanted into NCG mice engrafted with human PBMCs. Mice were treated with PBS and doses of αB7-H3/CD3 twice a week post tumor development; (b,d) average tumor growth curve of U-87 MG (b) and SKOV3 (d) xenografts for every group. The tumor volume was plotted against the time in days following antibody administration. The number of mice is shown in figures; (e) images of individual xenograft tumors at the end of experiments; (f) immunofluorescence staining analysis of CD3+ T cells (red) in U-87 MG tumors. Scale bar, 100 μm. bsAb, αB7-H3/CD3.