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Effect of simulated microgravity on MMP-9 (A) and MMP-2 (B) activity in human dermal fibroblasts. Gelatin zymography shows MMP-9 and MMP-2 activity in conditioned media of human fibroblasts exposed or unexposed to the RPM for 24 h. Values are expressed as a fold increase of on-ground control (OG). Each column represents the mean value ± SD of three independent experiments, where SD is depicted as vertical bars. ** p < 0.01 RPM versus OG by unpaired two-tailed t-test.
