FIG. 4.

Differences between HOXB3- and HOXA9-induced AMLs. (A) Main characteristics of the AMLs that developed in HOXB3, HOXB3-MEIS1, HOXA9, and HOXA9-MEIS1 bone marrow chimeras. a, Results are expressed as the means ± standard deviations for the indicated number of mice. b, Determination of the proportion of immature and mature cells in hematopoietic tissue of the leukemic mice was based on morphological criteria, i.e., mature cells with segmented nuclei and immature cells, blast-like. For each tissue sample, n = 200 cells were counted from n = 3 representative mice in each group. infilt., infiltration; non-hem., nonhematopoietic. (B) Wright staining of peripheral blood smears (PBL) and bone marrow (BM) cytospins from representative leukemic HOXB3, HOXB3-MEIS1, HOXA9, and HOXA9-MEIS1 mice. Magnification, ×100 for all. n, neutrophil; b, blast.