Figure 6.

Interaction of ACE2 with different ligands. (A) Interaction of a landscape phage displaying the peptide DGRADLSYD on the full-length p8 protein (yellow) with ACE2 (blue) as determined using homology modeling. Here, a segment containing less than 1% of the landscape phage is presented, where the DGRADLSYD peptide is presented as an N-terminal fusion to all copies of the mature p8 major coat protein. Molecular model 6M0J demonstrating the interaction between ACE2 protein (blue) and recombinant SARS-CoV-2 spike RBD (pink) with amino acid clusters corresponding to phage mimotopes. (B) DGRADLSYD; (C) VGIDEQRAD; and (D) DGRSIVGDE, highlighted in red.