Figure 8.

Interaction of fibroblast growth factor receptor 3 (FGFR3) with different ligands: (A) Interaction of a landscape phage displaying the peptide EDYSELVSQ (yellow) on the full-length p8 protein with FGFR3 (cyan), as determined using homology modeling. Here, a segment containing less than 1% of the landscape phage is presented, where the EDYSELVSQ peptide is presented as an N-terminal fusion to all copies of the mature p8 major coat protein. Interaction of FGFR3 (cyan) with (B) FGF1 (gray), (C) NRP1 (magenta), or (D) SARS-CoV-2 spike RBD (blue), with amino acid clusters containing alignments to the EDYSELVSQ mimotope highlighted in red.