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An illustration of main oligonucleotide mechanism of action as divided into two main groups: (1) Occupancy-only and (2) occupancy-mediated degradation. In occupancy only, oligonucleotide would act as steric blocker or inhibitor preventing any upcoming interaction with precedent targets. Meanwhile, occupancy-mediate degradation activates cleavage the targeted RNA via RNase or AGO-2.
