Table 2.

Pharmacokinetic parameter of Chol-hsiRNA after intravenous injection adapted by Godinho et al.

Parameter (Units)	Chol-hsiRNA
k(min−1)	0.0013
t1/2α(min)	515.8
t1/2β (min)	33.2
Cmax (µg/mL)	753.4
AUC0–48 h (µg/mL·min)	54,532.5
AUC0-inf (µg/mL·min)	54,807.5
MRT0-inf (min)	156.9
Vz (mL)	6.8
Cl (mL/min)	0.0091