Table 3.
A selective example of ON conjugated with lipoid moieties in corresponding with each bioconjugates section.
| Sequences | Spacer | Conjugates (X) | Source |
|---|---|---|---|
| Passenger 5’-CUUACCGACUGGAAGA-3’-X Guide 3’-CCGGACGGGAGCGCCGAAUGGCUGACCUUCU-5 |
N/A | Cholesterol | Hwang et al. |
| X-5’-TAGGGTTAGACAA-3’ |
|
Palmitic acid (16C) | Herbert et al. |
| X-5’-TCAACAATAAATACCGAGG-3’ |
|
α-tocopherol | Østergaard et al. |
| Sense X-5’-GGAGGAACUCUCCUGAUGAAU-3’ Anti-sense 5’-UCAUCAGGAGAGUUCCUGCCG-3’ |
|
Squalene | Massaad-Massade et al. |
Notation: red—2’MOE modification, green—cET modification, underline—PS backbone modification, and X—bioconjugates.