Figure 6.
Priming with rBCG-S1PT increases the protection against C. albicans challenge. (A) Groups of SCID mice (n = 10/group) were primed with 106 CFU of BCG or rBCG-S1PT and challenged 2 weeks later with C. albicans. The mice were followed for survival for 8 weeks after infection. (B) Using other groups of mice (n = 5/group), kidneys were collected one week after the challenge, and C. albicans CFU was evaluated. The results are representative of two and three experiments, respectively. The statistical significance of survival was determined via Log-rank (Mantel-Cox) test, and CFU via Mann–Whitney U test. * p < 0.05 vs. saline control. ns = not significant. Bars represent the mean ± SEM of values from the kidneys of five mice.