Table 2.
Antifungal MIC distributions, modal MICs, MIC90s and proportions of Trichophyton isolates that are considered NWT for terbinafine, itraconazole and voriconazole.
| Species | Drug | MICs (mg/L) | MICs (n) | Modal | MIC90 | Range | %>tECOFF | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.004 | 0.008 | 0.016 | 0.03 | 0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | > 4 | ND | |||||||
| T. rubrum | TERB | 1 | 3 | 8 | 7 | 1 | 2 | 7 | 4 | 1 | 6 | 3 | 8 | 43 | ND | ND | ≤0.004–>4 | 55.8 | |
| n = 51 | ITRA | 9 | 8 | 14 | 9 | 2 | 1 | 1 | 7 | 44 | 0.06 | 0.125 | ≤0.016–4 | 4.5 | |||||
| VOR | 2 | 7 | 20 | 13 | 2 | 7 | 44 | 0.06 | 0.125 | ≤0.016–0.25 | 4.5 | ||||||||
| ISCO | 9 | 11 | 17 | 5 | 9 | 42 | 0.06 | 0.125 | ≤0.016–0.125 | ||||||||||
| POS | 4 | 11 | 15 | 12 | 2 | 7 | 44 | 0.06 | 0.125 | 0.016–0.25 | |||||||||
| OLO | 3 | 5 | 18 | 13 | 3 | 9 | 42 | 0.016 | 0.03 | 0.004–0.06 | |||||||||
| 0 | |||||||||||||||||||
| T. indotineae | TERB | 2 | 3 | 2 | 7 | 4 | ND | 2–>4 | 100 | ||||||||||
| n = 7 | ITRA | 4 | 2 | 1 | 7 | 0.016 | ND | ≤0.016–0.06 | 0 | ||||||||||
| VOR | 1 | 3 | 2 | 1 | 7 | 0.125 | ND | 0.06–0.5 | 0 | ||||||||||
| ISCO | 1 | 2 | 2 | 2 | 7 | ND | ND | 0.06–0.5 | |||||||||||
| POS | 1 | 3 | 1 | 1 | 1 | 7 | 0.016 | ND | 0.008–0.125 | ||||||||||
| OLO | 2 | 3 | 1 | 1 | 6 | 0.016 | ND | 0.008–0.03 | |||||||||||
| T. interdigitale | TERB | 1 | 1 | 2 | 4 | ND | ND | ≤0.004–0.016 | 0 | ||||||||||
| n = 4 | ITRA | 2 | 1 | 1 | 4 | ND | ND | ≤0.016–0.06 | 0 | ||||||||||
| VOR | 2 | 1 | 1 | 4 | ND | ND | 0.06–0.25 | 0 | |||||||||||
| ISCO | 1 | 1 | 1 | 1 | 4 | ND | ND | ≤0.016–0.06 | |||||||||||
| POS | 3 | 1 | 4 | ND | ND | 0.03–0.06 | |||||||||||||
| OLO | 3 | 1 | 4 | ND | ND | 0.008–0.016 | |||||||||||||
TERB: terbinafine; ITRA: Itraconazole; VOR: Voriconazole; ISCO: Isavuconazole, POS: Posaconazole; OLO: Olorofim. Dotted red lines show the EUCAST tentative ECOFFs. T. interdigitale isolates were considered WT if below the T. indotineae tECOFF and having a unimodal distribution. Colour coding used to indicate the most common MICs for terbinafine (the darker the colour, the more isolates with a given MIC). Truncated ranges are marked in grey. Modal MICs are underscored. NWT MICs (MICs above the tECOFF) are marked in bold. The isolate of T. benhamiae had the following MICs: TERB and OLO: 0.016 mg/L; POS and ITRA: 0.125 mg/L; VOR and ISCO: 0.25 mg/L.