Table 3.
Terbinafine MICs (mg/L) in relation to SQLE profiles of Trichophyton isolates. The EUCAST tECOFFS are inserted as dotted red lines.
| Species | SQLE Profile (Genbank Accession) |
MIC (mg/L) | N | % NWT /SQLE |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.004 | 0.008 | 0.016 | 0.03 | 0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | >4 | NP | ||||
| T. rubrum | F397L (OM313306/OM313307) | 1 | 2 | 1 | 6 | 1 | 3 | 14 | 60.8 | |||||||
| F397I (OM313305) | 1 | 1 | 2 | |||||||||||||
| L393F (OM313304) | 2 | 2 | ||||||||||||||
| L393S (OM313303) | 2 | 5 | 7 | |||||||||||||
| Y414C/L438C (OM313302) | 1 | 1 | ||||||||||||||
| F415S (OM313301) | 1 | 1 | ||||||||||||||
| F415V (OM313300) | 1 | 1 | ||||||||||||||
| L437P (OM313299) | 1 | 1 | ||||||||||||||
| H440Y (OM313298) | 1 | 1 | ||||||||||||||
| I479V (OM313297) | 1 | 1 | ||||||||||||||
| WT (OM313296) | 1 | 3 | 7 | 6 | 1 | 2 | 20 | |||||||||
| T. indotineae | F397L (OM313310/ OM313311) | 2 | 2 | 1 | 5 | 63.6 | ||||||||||
| L393F (OM313308) | 1 | 1 | ||||||||||||||
| F397L/A448T (OM313309) | 1 | 1 | ||||||||||||||
| T. interdigitale | WT (OM313312) | 1 | 1 | 2 | 4 | |||||||||||
| T. benhamiae | WT (OM313313) | 1 | 1 | 0 | ||||||||||||
| Trichophyton spp. | Total | 2 | 4 | 11 | 7 | 1 | 2 | 7 | 4 | 3 | 9 | 5 | 8 | 63 | 60.3 | |
NP: Not possible. T. interdigitale isolates were considered WT if below the T. indotineae tECOFF and having a unimodal distribution. Numbers in red indicate isolates that are NWT, whereas numbers in green indicate WT isolates. Finally, numbers in orange indicate isolates with classification mismatch between SQLE profile and phenotypic resistance.