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Compound evaluation and rationale—from previous work to this project: The 18F-labeling of H-Tz has already been established (previous work); labeling of bispyridyl Tzs succeeded in this study. Bispyridyl Tzs have intrinsic high-reaction kinetics and allow higher chemical flexibility. Pyridyl unit A can be used to introduce the necessary polarity for in vivo pretargeting, whereas pyridyl unit B can be used for labeling purposes.
