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. 2022 Feb 18;15(2):245. doi: 10.3390/ph15020245

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Radiolabeling of [¹⁸F]45. (A) Reaction sequence. Reagents and conditions: (i) [¹⁸F] Bu₄NF/Bu₄NOMs PO₄^3-, t-BuOH/DMSO, 100 °C, 5 min; (ii) TFA, CH₃CN, 80 °C, 10 min. (B) Analytical chromatograms of formulated [¹⁸F]45 in PBS (pH = 7.4) spiked with nonradioactive 45 for identification (rt: 5.20 min). (C) Analytical chromatogram of the reaction between [¹⁸F]45 showing that the tetrazine core was intact. Analytical chromatogram of [¹⁸F]15 formulated before TCO-PNP addition (red) and after TCO-PNP addition (black).