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Reagents and conditions: (i) (a) NH2NH2.H2O, CH2Cl2, S8, EtOH, 50 °C, 24 h; (b) NaNO2, AcOH, 0 °C to rt, 30 min; (ii) 1-fluoro-2-iodoethane, DIPEA, DMF, 70 °C, 4 h; (iii) 2-bromoethanol, DIPEA, DMF, 70 °C, 4 h; (iv) nosyl chloride, DIPEA, DMAP, CH2Cl2, rt, 1 h; (v) 2-fluoroethylamine hydrochloride or ethanolamine, Et3N, CDI, CH3CN, 0 °C to rt, 12 h.
