Table 2.
Characteristics of multilayer casein/chitosan films loaded with benzydamine hydrochloride (MLF-BZ), tolfenamic acid (MLF-TA) and betahistine dihydrochloride (MLF-BET) compared to drug-free (placebo) films (MLF-PL), n = 3.
| Sample Code | Model Drug | Surface pH ± SD | Moisture Loss % ± SD | Moisture Absorption % ± SD | Mucin Adsorption% ± SD | Drug Content µg ± SD |
|---|---|---|---|---|---|---|
| MLF-PL | - | 6.36 ± 0.07 | 1.95 ± 0.28 | 0.75 ± 0.09 | 60.26 ± 0.28 | - |
| MLF-BZ | Benzydamine hydrochloride | 5.97 ± 0.15 | 1.17 ± 0.24 | 2.46 ± 0.24 | 65.04 ± 1.12 | 90.48 ± 2.65 |
| MLF-TA | Tolfenamic acid | 6.80 ± 0.16 | 0.84 ± 0.11 | 4.99 ± 0.91 | 66.32 ± 1.02 | 977.33 ± 11.76 |
| MLF-BET | Betahistine dihydrochloride | 6.51 ± 0.13 | 1.27 ± 0.12 | 3.04 ± 0.69 | 70.84 ± 0.36 | 95.71 ± 3.21 |