Table 2.

Potential moderators for the effectiveness of psilocybin in treating depressive symptoms ^a.

Variable	Estimate	SE	Z-Value	p-Value
Dose	−1.89	0.84	−2.25	0.02 *
Size	−0.002	0.01	−0.17	0.86
Age	0.01	0.02	0.4	0.64
Female	0.28	0.52	0.54	0.59
Study Duration (Month)	0.02	0.07	0.33	0.74
MDD vs Cancer	−0.28	0.28	−1.02	0.31
Two Doses vs Single Dose	−0.50	0.26	−1.96	0.049 *
Severity (Severe vs Non-severe)	−0.29	0.28	−1.02	0.31
RCT vs Non-RCT	0.20	0.27	0.74	0.46
With vs Without Psychotherapy	−0.37	0.33	−1.11	0.26
Placebo-controlled vs Pre-post Change	−0.27	0.30	−0.89	0.37

Abbreviation: MDD, major depressive disorder; RCT, randomized controlled trial; SE, standard error. * p < 0.05. ^a Meta-regression analyses were performed in the model of multivariate meta-analysis.