Figure 2.

The influence of baseline anxiety symptoms on treatment outcome in the pivotal RCT [13]. Between-group (i.e., H1 Coil–Sham) differences in anxiety and depression outcomes during the treatment, with the subjects split into two sub-groups selected to reflect differences in the severity of anxiety at baseline (i.e., Low Anxiety sub-group: baseline HAM-A < 21 points, High Anxiety sub-group: baseline HAM-A ≥ 21 points). Between-group changes in (A) HAM-A anxiety score and (B) HDRS-21 overall depression score until the primary study endpoint are shown (i.e., baseline–endpoint indicated by Δ). A significant improvement in the performance of the H1 Coil relative to Sham for both measures was found in the sub-group with high anxiety at baseline. Error bars are ± SEM. * indicates a significant between-group difference (p < 0.05).