ACPA	anti-citrullinated protein antibody
ADA	adalimumab
CZP	certolizumab pegol (CZP)
bDMARDs	biological disease-modifying antirheumatic drugs
csDMARDs	conventional synthetic disease-modifying antirheumatic drugs
ERK1/2	extracellular signal-regulated kinase 1/2
ETA	etanercept
EULAR	European League Against Rheumatism
FcγR	Fc-gamma receptor
FISH	fluorescence in situ hybridization
FLS	fibroblast-like synoviocytes
GOL	golimumab
IFN-γ	interferon-γ
IHC	immunohistochemistry
IL-17	interleukin-17
IFX	infliximab
i.v.	intravenously
JNK	c-jun N-terminal kinase
MLS	macrophage-like synoviocytes
NGS	next generation sequencing
PEG	polyethylene glycol
PBMCs	peripheral blood mononuclear cells
RA	rheumatoid arthritis
RANKL	receptor activator of NF-κB ligand
ROS	reactive oxygen species
s.c.	subcutaneously
SNP	single-nucleotide polymorphism
TACE	TNF-alpha-converting enzyme
TLR	Toll-like receptor
sTNF	soluble Tumor Necrosis Factor
tmTNF	transmembrane Tumor Necrosis Factor
TNFR1/2	Tumor Necrosis Factor receptor 1/2
VEGF	vascular endothelial growth factor
WGS	whole genome sequencing
WES	whole exome sequencing