Figure 1.

(A) Comparison of the binding modes of VEGF-A₁₆₄ (in orange stick representation) and SARS-CoV-2 (in green stick representation) CendR motifs by superimposing VEGF-A-NRP1 (PDB ID: 4DEQ; [17] NRP1 in orange cartoon representation) and SARS-CoV-2-NRP1 (PDB ID: 7JJC; [6] NRP1 in green cartoon representation) complexes. (B) Zoomed view representing SARS-CoV-2 CendR binding mode into the b1 domain of NRP1, highlighting interactions with the key amino-acid residues (in green stick representation). Hydrogen bonding and salt bridge interactions are depicted as yellow and violet dashes, respectively.