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. 2022 Feb 19;15(2):251. doi: 10.3390/ph15020251

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Motor impairments instigated by diiodohydroxyquinoline administration in young/adult male/female rats. Panels represent: (A) distance traveled (OFTD), (B) mean speed (OFTMS), (C) time immobile (OFTTI), (D) central time (OFTCT), (E) central distance (OFTCT), and (F) thigmotaxis time (OFTTT) in the open field test as well as (G) fall off latency (RRFOL) in the rotarod test. Each bar with a vertical line represents the mean ± S.D. of 10 rats per group. a vs. control young male, b vs. control young female, c vs. control adult male, d vs. control adult female, e vs. DHQ young male, f vs. DHQ young female, and g vs. DHQ adult male using three-way ANOVA followed by Tukey’s post hoc test; p < 0.05. DHQ; diiodohydroxyquinoline.