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. 2022 Feb 12;11(4):956. doi: 10.3390/jcm11040956

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) with a metal film. (A): Overview of SALDI-MS. Tissue samples are first cut using a microtome to obtain tissue sections and then mounted on glass slides. The samples are then coated with platinum (Pt) film using the sputtering method. Finally, the Pt film is irradiated with a UV pulsed laser, and the ions produced from the sample are detected. (B): Ion intensity of pregnenolone by MALDI and SALDI-MS. The average ion intensities are shown for MALDI and SALDI with Pt film (Pt-SALDI). Error bars represent the means ± standard deviations of five experiments. (C): Localization of [M+H]⁺ ions as a mass image of pregnenolone at m/z 339.229 obtained by SALDI-MS imaging of ferret adrenal glands.