Table 4.
Overview of the chemically synthesized and natural compounds used to minimize neurotoxicity of Hg, dating from 2010 to the present.
| Chemically Synthesized or Natural Compound | Hg Type | Experimental Model | Results | Reference |
|---|---|---|---|---|
| Celosia argentea and vitamin E | HgCl2 | Rats | Protected against the Hg-induced gross, oxidative, cerebral and cerebellar damage | [161] |
| Launaea taraxacifolia | HgCl2 | Rats | Mitigated the Hg-induced behavioural changes and alteration of the microanatomy of cerebral cortex, hippocampus and cerebellum | [162] |
| Citrullus lanatus seed extract and Vitamin E | HgCl2 | Rats | Protected against the Hg-induced degeneration of frontal cerebral cortical neurons | [163] |
| Curcumin | HgCl2 | Rats | Detoxification and antioxidant effects | [164] |
| HgCl2 | Rats | Ameliorated the behavioural and biochemical alterations in the offspring | [165] | |
| Diallyl sulphide (DAS) | HgCl2 | Rats | Counteracted the oxidative damage and increased the anti-inflammatory response against the Hg-induced neurotoxicity | [166] |
| Dendropanax morbifera Léveille | Dimethylmercury-(CH3)2Hg | Rats | Reduced the Hg levels in hippocampal homogenates and increased the activities of antioxidant enzymes | [167] |
| Bacopa monniera | MeHg (CH3Hg) | Rats | Protected against the Hg-induced OS | [168] |
| Grape Seed Proanthocyanidin Extracts | CH3Hg | Rats | Counteracted the oxidative damage | [169] |
| Vitamin K | CH3Hg | Primary cultured neurons from the cerebella of rat pups | Protected the neurons against Hg cytotoxicity | [170] |
| Sodium selenite (Na2SeO3) | CH3Hg | Rats | Modulated the autophagic and apoptotic milieu of the cells via inhibiting the ROS-mediated apoptosis | [171] |
| NAC | CH3Hg | Rats | Reduced the Hg-induced toxicity in the developing rat hippocampus | [172] |