Figure 2.

Resuming the best strategy for a successful translation of Microbiome-based concepts into cosmetic products of the future. Combined approaches of multi-omics technologies, powerful data mining tools, and representative 3D vitro skin models associated with standardized and unbiased experimental approaches dedicated to skin Microbiome analysis are key. Harnessing recent scientific breakthroughs and deciphering the famous causality question allied to better characterization of the interaction between the microbiome, the immune system and skin cells in various skin conditions would accelerate the translation. Finally, consideration of regulatory and safety aspects related to these new/targeted Microbiome-derived technologies (postbiotics, phages, probiotics…) and how to leverage their performance in different formulation types is essential.