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. 2022 Jan 21;15(2):125. doi: 10.3390/ph15020125

Figure 5.

Figure 5

Mechanisms of the effects of (R)-ketamine coadministered with LY341495 in the CUMS model of depression. (A) schedule of experiments and effects of NBQX or ANA-12 pretreatment on the antidepressant-like effects of the mix RL in the splash test; (B) schedule of experiments and effects of NBQX or ANA-12 pretreatment on the antidepressant-like effects of the mix RL in the sucrose preference test; (C) schedule of experiments and effects of NBQX or ANA-12 pretreatment on the antidepressant-like effects of the mix RL in the TST. The values are expressed as the means ± SEM and were analyzed by two-way ANOVA. @ p < 0.05, @@ p < 0.01, @@@ p < 0.001 drug × drug interaction; ## p < 0.01, #### p < 0.0001 mix RL main effect; * p < 0.05, **** p < 0.0001 (CUMS effect, t test) (N = 10–12). Mix RL–(R)-ketamine 1 mg/kg + LY 341495 0.3 mg/kg.