Table 1.

The genetic contributions to cancer. Prevalence of heritable cancers as compared with the estimated heritability of cancers.

Cancer Type	Number of Cases/Year in USA (2021)	Germline Prevalence (%)	Familial Prevalence (%)	GWAS Heritability (%)	Twin Heritability (%)
Breast	281,550 [55]	5.7–11.1 [21,22,23] Ave. = 8.4	13.6 [20]	9.7 [40]	31 [18]
Prostate	248,530 [55]	2.9–17.2 [24,25,26] Ave. = 10.1	20.2 [20]	11.0 [41]	57 [18]
Lung	235,760 [55]	0.3–1.4 [27,28,29] Ave. = 0.9	8.7 [20]	0.7 [42]	18 [18]
Colorectal	149,500 [55]	3.5–7.5 [30,31] Ave. = 5.5	12.8 [20]	1.2 [43]	15 [18]
Melanoma	106,110 [55]	1.9–3.1 [32,33] Ave. = 2.5	4.9 [20]	0.9 [44]	58 [18]
Bladder	83,730 [55]	8.9 [34]	5.4 [20]	0.9 [45]	30 [18]
Non-Hodgkin Lymphoma	81,560 [55]	7.7 [35]	2.9 [20]	0.7 [46]	25 [19]
Kidney (RCC)	76,080 [55]	7.9 [36]	3.6 [20]	0.6 [47]	38 [18]
Endometrial Uterine	66,570 [55]	4.6 [37]	4.1 [20]	0.6 [48]	27 [18]
Pancreatic	60,430 [55]	3.9 [38]	3.7 [20]	0.6 [49]	36 [52]
Thyroid	44,280 [55]	NA	3.5 [20]	1.5 [50]	53 [53]
Liver/bile Duct	42,230 [55]	5.9 [39]	2.6 [20]	1.7 [51]	30 [54]
Range		0.3–17.2	2.6–20.2	0.6–11.0	15.0–57.0
Case-weighted average		6.2	10.2	4.3	34.2