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. Author manuscript; available in PMC: 2022 Jun 11.
Published in final edited form as: Rev Mod Phys. 2021 Jun 11;93(2):025008. doi: 10.1103/revmodphys.93.025008

FIG. 5.

FIG. 5

(A) Plots of a “two-state” model composed of only monomers (n = 1) and aggregates of a single peak size (n = n* ≈ nT) as functions of the total concentration Φ and for different finite aggregate sizes. The critical aggregation concentration (CAC), here ϕ*, characterizes the concentration range beyond which aggregates dominate the subunit population. (B) Assembly behavior of hepatitis B virus (HBV) capsid protein in vitro as a function of concentration. The plot shows the concentration-dependence of the fraction of subunits (protein dimer) in two states: free subunits and assembled capsids composed of 120 subunits. Notice that as the total concentration crosses the CAC (labeled KD,app), the concentration of free subunits is nearly constant, with almost all additional subunits assembling into capsids. Figure in (B) reprinted from (Ruan et al., 2018).