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. 2022 Jan 31;14(2):338. doi: 10.3390/pharmaceutics14020338

Figure 2.

Figure 2

PEA promotes adipose tissue remodeling, restores leptin signaling and reduces inflammation in HFD animals. (A) Representative H & E of the paraffine-embedded alternate section of scWAT for all experimental groups (n = 7 animals for each group). (B) The mean of adipocyte size in scWAT is also shown. (C) Real-time PCR of leptin receptor (LepR) and protein expression of (D) phospho-STAT3 and (E) SOCS3 are evaluated in scWAT (n = 5–7 each group). (F) The mRNA transcription of Il6, Tnf, and AdipoQ in scWAT are measured (n = 5–6 each group). Results are shown as mean ± SEM. * p < 0.05, **** p < 0.0001 significantly different from STD; # p < 0.05, ## p < 0.01, ### p < 0.001 from HFD.