Table 2.

Recapitulative table of the described nanosystems that encapsulate PTM

Class of nanocarrier	Nanocarrier composition	PTM form	Preparation technique	Development phase	Admin. route	Pathology	Ref
Lipidic	Mannose-grafted liposomes	Isethionate salt	Thin lipid evaporation and hydration method	In vivo leishmaniasis hamster model	s.c	Leishmaniasis	Banerjee et al. [105]
	PEG-coated liposomes	Free base or isethionate salt	Thin lipid evaporation and hydration method or transmembrane gradient	In vitro test on a cancer cell line	/	Cancer	Stella et al. [148]
	PEG-coated liposomes	Isethionate salt	Thin lipid evaporation and hydration method	In vivo cancer mouse models	i.v	Cancer	Merian et al. [149]
Polymeric	Polymethacrylate	Isethionate salt	Emulsion polymerization	In vivo	i.v	Leishmaniasis	Paul et al. [112]
				BALB/c
	Methacrylate	Methane sulfonate solution	Emulsion polymerization	In vivo	i.v	Leishmaniasis	Durand et al. [115]
				BALB/c
	PCL	Isethionate salt	Double solvent evaporation	In vitro brain endothelial cells	/	Leishmaniasis	Omarch et al. [116]
	PEG-chitosan	Isethionate salt	Coacervation method	In vivo T. brucei mouse model	i.p	Trypanosomiasis	Unciti-Broceta et al. [119]
	PLA	Free base	Nanoprecipitation	In vivo BALB/c	i.v	Leishmaniasis	Paul et al. [112, 123] and Durand et al. [125]
	PEG-PLGA-PTM bioconjugate	Isethionate salt	Water/oil emulsion method	In vitro L. infantum amastigote-infected macrophages	/	Leishmaniasis	Scala et al. [127]
	PEG-PLGA	Not specified	Water-in-oil-in-water double emulsion/solvent evaporation	In vivo African trypanosomiasis mouse model	i.p	Trypanosomiasis	Arias et al. [128]
	PLGA	Free base	Water-in-oil-in-water double emulsion/solvent evaporation	In vivo leishmaniasis mouse model	s.c./os	Leishmaniasis	Valle et al. [129]
	Cyclodextrins	Isethionate salt	/	In vivo leishmaniasis mouse model	i.v./os	Leishmaniasis	De Paula et al. [134]
	Hyaluronic acid and polyarginine	Isethionate salt	Polyelectrolyte complexation	In vitro tests on cancer cell lines	/	Cancer	Carton et al. [147]
	PLGA and PEG-PLGA	Free base	Nanoprecipitation	In vitro test on a cancer cell line	/	Cancer	Stella et al. [148]
	Polysorbate 20, cholesterol, dicetyl phosphate, chitosan (niosomes)	Isethionate salt	Thin film hydration method	Physico-chemical characterization	/	Alzheimer’s disease	Rinaldi et al. [141]
	Polysorbate 20, cholesterol, dicetyl phosphate, chitosan (niosomes)	Isethionate salt	Thin film hydration method	In vivo Parkinson’s disease mouse model	Nasal	Parkinson’s disease	Rinaldi et a. [143]
	Polysorbate 20, cholesterol, dicetyl phosphate, chitosan (niosomes)	Isethionate salt	Thin film hydration method	In vitro tests on human biopsies	/	Cancer	Seguella et al. [145]
Inorganic	Functionalized mesoporous silica	Free base or isethionate salt	Sol–gel method and functionalization	Physico-chemical characterization	/	/	Peretti et al. [151]
	PEG-gold	Not specified	Seed-mediated growth and PEGylation	In vitro tests on cancer cell lines	/	Cancer	Her at al. [153]