Table 2.

Cytotoxic activities of enantiomers. (a) part 1; (b) part 2.

Cell lines	Compds.	IC50 (μM)	Reference	Cell Lines	Compds.	IC50 (μM)	Reference
(a)
HL-60	(+)-171a	5.62	[105]	HCT-116	(−)-314a	1.38	[162]
	(−)-171b	3.51	[105]		(+)-314b	>10	[162]
	(±)-171	2.65	[105]	HepG2	(−)-314a	3.30	[162]
	(+)-172a	9.64	[105]		(+)-314b	>10	[162]
	(−)-172b	8.16	[105]	BGC-823	(−)-314a	6.51	[162]
	(±)-172	5.58	[105]		(+)-314b	>10	[162]
Hep3B	(−)-268a	>10	[146]	NIC-H1650	(−)-314a	8.19	[162]
	(+)-268b	5.1	[146]		(+)-314b	>10	[162]
HL-60	(+)-297a	12.08	[156]	A2780	(−)-314a	2.14	[162]
	(−)-297b	19.24	[156]		(+)-314b	>10	[162]
MDA-MB-231	(+)-297a	>50	[156]	SF-268	(+)-536a	12.5	[261]
	(−)-297b	18.46	[156]		(−)-536b	>100	[261]
HCT-116	(+)-312a	inactive	[160]		(+)-537a	30.1	[261]
	(−)-312b	14.23	[160]		(−)-537b	>100	[261]
A549	(−)-390a	4.64	[8]	HepG2	(+)-536a	15.0	[261]
	(+)-390b	10.54	[8]		(−)-536b	>100	[261]
MCF-7	(−)-390a	5.60	[8]		(+)-537a	37.3	[261]
	(+)-390b	15.52	[8]		(−)-537b	>100	[261]
MDA-MB-231	(−)-390a	3.86	[8]
	(+)-390b	11.86	[8]
(b)
HL-60	(+)-381a	3.42	[191,192]	MCF-7	(+)-381a	4.18	[191,192]
	(−)-381b	>20	[191,192]		(−)-381b	>20	[191,192]
	(−)-382a	16.54	[191,192]		(−)-382a	14.44	[191,192]
	(+)-382b	>40	[191,192]		(+)-382b	>40	[191,192]
	(±)-382	14.44	[191,192]		(±)-382	36.00	[191,192]
	(−)-383a	3.15	[191,192]		(−)-383a	5.85	[191,192]
	(+)-383b	2.35	[191,192]		(+)-383b	10.76	[191,192]
	(±)-383	18.08	[191,192]		(±)-383	17.05	[191,192]
	(−)-384a	3.45	[191,192]		(−)-384a	3.17	[191,192]
	(+)-384b	2.36	[191,192]		(+)-384b	3.08	[191,192]
	(±)-384	2.93	[191,192]		(±)-384	11.92	[191,192]
	(−)-385a	2.63	[191,192]		(−)-385a	14.60	[191,192]
	(+)-385b	5.41	[191,192]		(+)-385b	15.02	[191,192]
	(±)-385	13.90	[191,192]		(±)-385	15.47	[191,192]
SMMC-7721	(+)-381a	4.19	[191,192]	SW480	(+)-381a	7.22	[191,192]
	(−)-381b	>20	[191,192]		(−)-381b	>20	[191,192]
	(−)-382a	16.20	[191,192]		(−)-382a	17.43	[191,192]
	(+)-382b	>40	[191,192]		(+)-382b	>40	[191,192]
	(±)-382	22.83	[191,192]		(±)-382	27.73	[191,192]
	(−)-383a	5.55	[191,192]		(−)-383a	3.04	[191,192]
	(+)-383b	12.30	[191,192]		(+)-383b	5.53	[191,192]
	(±)-383	20.71	[191,192]		(±)-383	13.60	[191,192]
	(−)-384a	3.80	[191,192]		(−)-384a	1.99	[191,192]
	(+)-384b	10.83	[191,192]		(+)-384b	1.52	[191,192]
	(±)-384	15.36	[191,192]		(±)-384	7.62	[191,192]
	(−)-385a	12.53	[191,192]		(−)-385a	3.39	[191,192]
	(+)-385b	13.21	[191,192]		(+)-385b	4.31	[191,192]
	(±)-385	14.82	[191,192]		(±)-385	8.84	[191,192]
A549	(+)-381a	4.51	[191,192]	A549	(±)-383	24.02	[191,192]
	(−)-381b	>20	[191,192]		(−)-384a	2.96	[191,192]
	(−)-382a	17.27	[191,192]		(+)-384b	18.78	[191,192]
	(+)-382b	>40	[191,192]		(±)-384	15.44	[191,192]
	(±)-382	17.30	[191,192]		(−)-385a	22.36	[191,192]
	(−)-383a	4.40	[191,192]		(+)-385b	9.53	[191,192]
	(+)-383b	16.33	[191,192]		(±)-385	10.24	[191,192]