Table 3.

Antiviral activities of enantiomers ^a.

Virus/Host	Compds.	EC50 (μM)	IC50 (μM)	SI	Reference
HSV-1/Vero	(+)-254a	6.41	19.25	3.0	[7]
	(−)-254b	3.70	16.02	4.3	[7]
	(±)-254	1.23	2.14	1.7	[7]
	Acyclovir b	>100	0.41	>243.9	[7]
Virus A (H3N3)/MDCK	(+)-104a	9.86	19.25	1.9	[67]
	(−)-104b	11.11	77.61	6.9	[67]
	(±)-104	3.13	6.42	2.1	[67]
	(−)-105a	8.62	77.61	7.9	[67]
	(+)-105b	17.46	57.74	3.3	[67]
	(±)-105	2.87	25.87	9.0	[67]
	Oseltamivir b	3.38	3073	910.5	[67]
	Ribavirin b	6.19	4771	770.7	[67]
KSHV/Vero	(+)-368a	8.75	140.6	16.06	[184]
	(−)-368b	29.13	173.7	5.96	[184]
	(+)-369a	202.9	>500	>2.46	[184]
	(−)-369b	140.9 17.67	>500	>2.55	[184]
	(+)-370a		211.1	12.51	[184]
	(−)-370b	39.80	>300	>7.50	[184]
	(+)-371a	40.00	>300	>7.50	[184]
	(−)-371b	158.50	>300	>1.89	[184]
	Acyclovir b	0.41	99.18	241.9	[184]
EV71/Vero	(−)-558a	69.1	143.7	2.1	[272]
	(+)-558b	14.2	130.2	9.2	[272]
	(±)-558	14.2	126.6	7.9	[272]
	Ribavirin b	>256.1	4098	>16	[272]

^a EC₅₀ represents concentration required to inhibit virus growth by 50%; IC₅₀ represents concentration required to inhibit host cell growth by 50%; SI (Selectivity index) = IC₅₀/EC₅₀. ^b Positive controls.