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. 2022 Feb 11;23(4):2008. doi: 10.3390/ijms23042008

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Changes in mRNA expression of Nrf2 cytoprotective target genes. (A) PL, TAC, and TAC/PL treatments reduced expression of Nrf2. (B) PL, TAC, and TAC/PL treatments reduced expression of GCLM. (C) TAC and TAC/PL treatments increased expression of GCLC. (D) TAC treatment increased expression of Nqo1. (E) TAC and TAC/PL treatments reduced expression of Hmox1. (F) PL, TAC, and TAC/PL treatments reduced expression of Txnrd1. One-way ANOVA, average ± SEM; Bonferroni multiple comparisons * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. DMSO, n = 7; PL, n = 9; TAC, n = 8; TAC/PL, n = 6.