Table 4.
Top 5 canonical pathways affected by TAC treatment, as highlighted by IPA.
| Pathway Name | p-Value | IPA Ratio |
|---|---|---|
| EIF2 signaling | 1.000 × 10−11 | 0.0848 |
| Mitochondrial dysfunction | 1.000 × 10−10 | 0.0936 |
| Oxidative phosphorylation | 2.818 × 10−10 | 0.1190 |
| Synaptogenesis signaling pathway | 1.622 × 10−08 | 0.0577 |
| mTOR signaling | 1.122 × 10−07 | 0.0667 |
The IPA ratio is the number of molecules that meet criteria divided by the total number of pathway proteins in the IPA database. The p-value represents the probability of the ratio occurring by chance.