Table 5.
Top 5 networks associated with TAC/PL vs. TAC treatment.
| Network Rank | Molecules in Network |
|---|---|
| 1 | Associated network functions: post-translational modification, RNA post-transcriptional modification, cellular development Number of focus molecules in network: 26 IPA p-score: 61 Network proteins: ACOX1, AKT2, AMIGO1, ARL6IP1, Akap9, BIRC6, CG, ERK1/2, Hsp70, Hsp90, IL33, LIMCH1, MAP2K1/2, MB21D2, MRAS, NDRG4, NMT1, NMT2, NUDCD3, NUDT5, PMPCB, POLR2A, PP1 protein complex group, PPP1R8, PRMT5, PRPF4B, SCRIB, Snrpc, Sos, TMED9, WBP11, WDR54, YTHDF1, caspase, phosphatase |
| 2 | Associated network functions: cellular function and maintenance, nervous system development and function, tissue development Number of focus molecules in network: 19 IPA p-score: 40 Network proteins: 26s proteasome, ANKRD17, ATP5F1C, Akt, Ap1, BLVRB, CD3, CREB1, Calmodulin, Celf1, DDX46, ERK, GPR37, Histone h3, IGKC, Immunoglobulin, Insulin, LARP7, ME1, NFkB (complex), p-TEFb, P38 MAPK, PI3K (complex), PNN, PSMD3, RAS, RBMX, RNA polymerase II, SCAF8, SCARB2, TBC1D7, TCR, TRPM3, TUB, UBR4 |
| 3 | Associated network functions: cellular assembly and organization, cell morphology, cellular function, and maintenance Number of focus molecules in network: 16 IPA p-score: 32 Network proteins: ASB13, BAZ1B, CDC42BPA, CHST11, DCAKD, EPG5, FSCN2, GPR161, IRF2BPL, KLHL28, MFSD11, NCLN, PARD3B, PHACTR4, PHF3, RHOBTB2, RNF20, SPECC1L, SPRYD7, SYN3, TIMM23, TRIM25, UBA6, UBC, UBE2Q1, URM1, USP32, USP45, USP9Y, VCP, VIRMA, VPS35L, WASHC4, WASHC5, ZMIZ2 |
| 4 | Associated network functions: drug metabolism, endocrine system development and function, lipid metabolism Number of focus molecules in network: 13 IPA p-score: 25 Network proteins: ABHD4, ADGRL1, ANXA4, AP1M1, ARHGAP6, CCNT2, DFFB, HNRNPL, HRH3, HSD17B6, HTR4, ITIH4, JOSD2, NEK4, OMG, PCDHGB1, PDS5A, POMC, PRR5, PRUNE2, PTBP2, RAMP3, RBM10, SMC3, SPECC1, SRP54, STK32C, TATDN1, TBC1D5, TECTA, TENM2, VPS26C, VPS35L, ZFP64, beta-estradiol |
| 5 | Associated network functions: protein synthesis, cellular movement, hematological system development and function Number of focus molecules in network: 11 IPA p-score 20 Network proteins: ACY1, AKT1S1, ALDH5A1, APP, CPQ, CPT1C, D2HGDH, DGLUCY, DNAH1, DNAH14, DNAH2, DNALI1, ENO3, BXO3, FGF6, GATB, HCAR2, ITIH1, Ighg2b, LGMN, LMCD1, MBD4, METAP2, MRPS6, MTERF3, ROBO3, RPS6KC1, SHFL, SLAMF1, SPHK1, ST3GAL5, TGFB1, TRIM63, ZHX2, ceramide |
Qiagen IPA algorithm overlays focus molecules from the experimental dataset to the Global Molecular Network and generates a connectivity map. The p-score (log 10 (p-value) is calculated by Fisher’s exact test and is indicative of the probability of focus molecules in a network being selected randomly from the Global Molecular Network.