Table 6.
Top 5 canonical pathways affected by TAC/PL treatment compared to TAC alone, as highlighted by IPA.
| Canonical Pathways | p-Value | IPA Ratio |
|---|---|---|
| NGF signaling | 8.913 × 10−4 | 0.0351 |
| Apelin muscle signaling pathway | 2.291 × 10−3 | 0.1050 |
| ERK5 signaling | 2.512 × 10−3 | 0.0417 |
| Estrogen-dependent breast cancer signaling | 2.692 × 10−3 | 0.0405 |
| Hypoxia signaling in the cardiovascular system | 2.692 × 10−3 | 0.0405 |
The IPA ratio is the number of molecules that meet criteria divided by the total number of pathway proteins in the IPA database. The p-value represents the probability of the ratio occurring by chance.