Fig 1. Schematic overview of metabolic and volume-based ¹¹C-MET PET parameters.

(A) Snapshot of lesion with positive uptake of 11C-MET. (B) SUVmax is defined as voxel with highest uptake within the lesion. (C) SUVmean is an average of all SUV values from included voxels within the lesion. (D) SUVpeak is defined as the average value within a 1cm³ sphere surrounding the SUVmax. Volume-based parameters are shown in E-F. (E) MTV is the volume of increased uptake within the lesion borders. (F) For TLMM the SUVmean and MTV within lesion borders are combined and multiplied to provide both metabolic and volume-based information. TLMM is automatically calculated and extracted within the Syngo.via software. Abbreviations: MTV = metabolic tumor volume, SUV = standardized uptake value, TLMM = total lesion methionine metabolism.