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DKD progression rates vary among HFD-fed mice. (A) Urinary albumin/creatinine ratio (UACR) and urinary KIM-1/creatinine ratio (UKCR); (B) Renal protein expression of KIM-1 and antioxidant enzyme SOD2 (C) Histological staining: Hematoxylin and Eosin (H&E) and Pico-Sirius Red (PSR). * p < 0.05, ** p < 0.01, *** p < 0.001. HFD-2: mice with advanced kidney injury, HFD-1: mice with mild–moderate kidney injury.
