Table 1.

List of major transcriptional regulators for clyA gene expression.

Gene	Product/Function	Organisms	Relevant Descriptions	References
hns	heat-stable nucleoid-structuring protein	E. coli	strongly repress the transcriptional expression of clyA gene under laboratory condition	[12,13,28,29,39]
slyA	MarR-family transcriptional regulator	E. coli S. Typhimurium	activate the expression of clyA gene by antagonizing the H-NS–mediated transcriptional repression when overexpressing SlyA	[12,13,28,29,39]
mprA	MarR-family transcriptional regulator	E. coli	activate the expression of clyA gene by antagonizing the H-NS–mediated transcriptional repression when overexpressing MprA	[24]
fnr	fumarate and nitrate reduction regulator	E. coli	activate the expression of clyA gene in response to oxygen depletion	[33,35]
crp	cyclic AMP receptor protein	E. coli	activate the expression of clyA gene in response to glucose starvation	[33]
		S. Typhi	repress the transcriptional expression of clyA gene (on SPI-18) via down-regulating rpoS	[37]
phoP	transcriptional regulator (two-component regulatory system PhoP/PhoQ)	S. Typhi	up-regulate the expression of clyA gene (on SPI-18) via rpoS under low pH and low Mg2+	[36,38]
fis	DNA-binding protein	S. Typhi	down-regulate the expression of clyA gene (on SPI-18) in CRP-independent glucose-dependent manner	[38]
rpoS	RNA polymerase sigma factor	S. Typhi	relate to the transcriptional upregulation of clyA gene (on SPI-18) in low pH and high osmolarity condition (predicted central regulator in the clyA regulatory network)	[36,38]