Table 2.
Overview of steady-state fluxes and filtration times in relation to pre-concentration factors. For all processes, we applied rebuffering with 5 diavolumes and an overall process concentration factor of 8. For the pre-concentration factor of 2, we tested both continuous and discontinuous modes of diafiltration [37].
| Serum-Containing Medium | Serum-Free Medium | ||||
|---|---|---|---|---|---|
| Preconcentration Factor | Mode | Pseudo-Steady-State Flux | Filtration Time | Pseudo-Steady-State Flux | Filtration Time |
| (−) | (L m−2 h−1) | (h) | (L m−2 h−1) | (h) | |
| 1 | Continuous | 25.2 | 3.86 | 51.1 | 1.94 |
| 1.33 | Continuous | 27.1 | 3.03 | 56.9 | 1.44 |
| 2 | Continuous | 24.8 | 2.23 | 56.2 | 1.05 |
| Discontinuous | 26.1 | 2.07 | 65.8 | 0.92 | |
| 4 | Continuous | 26.8 | 1.32 | 62.7 | 0.63 |