Table 7.
Composition of prepared ODT tablets.
| Formulation | % Composition | Weight (mg) | |
|---|---|---|---|
| L-SNEDDS | Capmul MCM 20%, Cremophor EL 20%, PG 60% | 100 mg | |
| S-SNEDSS | L-SNEDDS: SYL (1:0.5) | 50 mg | |
| ODT excipients | Mannitol, Acdisol, lactose, Prosolv, Mg stearate | ~350 mg | |
| Ingredients | ODT-1 | ODT-2 | ODT-3 |
| Drug incorporated in S-SNEDDS | 110 | 110 | 110 |
| Lactose | - | 335 | - |
| Mannitol | - | - | 335 |
| Acdisol | - | 50 | 50 |
| Prosolv | 385 | - | - |
| Mg stearate | 5 | 5 | 5 |
| Total Weight (mg) | 500 | 500 | 500 |
Abbreviations: ODT, orally disintegrating tablets; L-SNEDDS, liquid self-nanoemulsifying drug delivery system; S-SNEDDS, solidified self-nanoemulsifying drug delivery system; SYL, Syloid.