Table 9.
The plasma pharmacokinetic parameters of the ODT tablet, commercial tablet and raw PGZ after a single dose oral administration to Wistar rats (mean ± SD, n = 6).
| Pharmacokinetic Parameter | ODT | ACTOS | Raw PGZ |
|---|---|---|---|
| Cmax (µg/mL) | 27.77 ± 2.55 | 17.40 ± 3.38 | 12.91 ± 2.24 |
| Tmax (h) | 3.4 ± 1.14 | 3.0 ± 1.00 | 3.0 ± 0.89 |
| AUC0−∞ (µgh/mL) | 313.05 | 185.32 | 151.36 |
| AUMC0−∞ (µg h2/mL) | 3461.02 | 1738.71 | 1652.14 |
| Kel (1/hr) | 0.18 ± 0.082 | 0.117 ± 0.013 | 0.126 ± 0.05 |
| t1/2(h) | 5.57 ± 4.94 | 5.95 ± 0.719 | 6.85 ± 4.35 |
| MRT (h) | 7.19 ± 0.96 | 7.87 ± 0.59 | 7.725 ± 0.84 |
Abbreviations: ODT, oral disintegrating tablet; PGZ, Pioglitazone Hydrochloride; Cmax: maximum plasma concentration; tmax: time to Cmax; AUC0−∞: total area under the concentration-time curve; AUMC0−∞: total area under the first moment curve; Kel, elimination rate constant; t1/2: elimination half-life; MRT, mean residence time.