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Independent variables’ levels and desirability constraints for the globule sizes used in Box–Behnken for the optimization of CTD-loaded GNE.
| Variables | Levels | |
|---|---|---|
| (−1) | (+1) | |
| A: Pumpkin oil concentration (%) | 10 | 30 |
| B: α-CD concentration (%) | 3 | 9 |
| C: Homogenization time (min) | 3 | 10 |
| Response | Desirability Constraint | |
| Globule size (GS, nm) | Minimize | |
