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CIA interaction with ERα is differentially regulated by SERMs. Ligand-dependent enhancement of the CIA-ERα interaction (lanes 3 and 4) is inhibited by the partial antagonists OHT and RAL (compare lanes 6 and 8 with lane 4) but is not significantly altered by the pure antiestrogens ICI 182,780 and EM-652 (compare lanes 10 and 12 with lane 4).
