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. 2022 Feb 16;15(2):232. doi: 10.3390/ph15020232

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Impact of FEB on TRPC1 (A) and CHOP (B) in 5-FU-induced parotid salivary gland toxicity. Values are expressed as the mean ± S.D. Results were considered significantly different when p < 0.05. ^a Significant difference compared to the control group, ^b significant difference compared to the FEB group, and ^c significant difference compared to the 5-FU group. (TRPC1: transient receptor potential canonical1; CHOP: C/EBP homologous protein; 5-FU: 5-Fluorouracil, and FEB: febuxostat) (8 rats/group).