Table 2.
Impact of FEB on oxidative stress parameters (MDA, SOD, GSH, and NOx) in 5-FU-induced injury of the parotid salivary gland in rats.
| Groups | MDA (nmol/g Tissue) |
SOD (U/g Tissue) |
GSH (μmol/g Tissue) |
NOx (nmol/g Tissue) |
|---|---|---|---|---|
| Control | 8.53 ± 1.08 | 371 ± 18.9 | 23.25± 2.61 | 7.42 ± 0.76 |
| FEB | 8.73 ±0.86 | 339 ± 39.2 | 22.54 ± 1.24 | 7.26 ± 0.87 |
| 5-FU | 17.56 ± 1.45 ab | 149 ± 16.75 ab | 17.81 ± 1.51 ab | 16.08 ± 0.71 ab |
| FEB + 5-FU | 9.62 ± 0.30 c | 339 ± 45.95 c | 22.83 ± 1.44 c | 10.80 ± 1.67 c |
The data are shown as the mean ± S.D (8 rats/group). a Significant difference relative to the control rats, b significant difference relative to the FEB group, and c significant difference compared to the 5-FU group. (MDA: malondialdehyde; SOD: superoxide dismutase; GSH: reduced glutathione; NOx: total nitrite/nitrate; 5-FU: 5-fluorouracil and FEB: febuxostat).