Fig. 6. Model for the Tsr2-mediated remodeling and repair of Rps26-deficient ribosomes.

(A) High intracellular Na⁺ concentrations or pH leads to ribosome remodeling by Tsr2-dependent dissociation of Rps26 from 40S ribosomes, producing Rps26-deficient ribosomes that display altered mRNA preference and enable translation of mRNAs from the Hog1 and Rim101 salt and pH response pathways (12). Removal of the stress allows for ribosome repair by allowing reincorporation of Rps26 from the Rps26·Tsr2 complex. (B) Rps26 binding to 40S ribosomes is Mg²⁺ and H⁺ dependent and involves two distinct sites.