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. 2022 Feb 5;14(2):365. doi: 10.3390/pharmaceutics14020365

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of arctiin on PI3K/Akt pathway in HeLa and SiHa cells. (A). After being treated with arctiin at a concentration of 0, 10, 20 and 40 μM for 24 h, the phosphorylation of ERK1/2, JNK1/2, p38, AKT and PI3K for HeLa and SiHa were analyzed by Western blotting assay. (B). After being treated with Akt activator SC-79 for 0, 15, 30, 60 and 120 min, the phosphorylation of AKT for SiHa were analyzed by Western blotting assay. After being treated with 20 μM arctiin in the presence or absence of SC-79 (10 μM) for 24 h, (C) the migrated cell number, (D) S100A4 protein expression and (E) S100A4 mRNA levels were analyzed. * p < 0.05, compared with the control group. # p < 0.05, comparison with the arctiin-treated group.